Base de dados : HANSEN
Pesquisa : LIGACAO PROTEICA [Descritor de assunto]
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Id:25121
Autor:Vardhini, Deena; Suneetha, Sujai; Ahmed, Niyaz; Joshi, D. S. M; Karuna, S; Magee, X; Vijayalakshmi, D. S. R; Sridhar, V; Karunakar, K. V; Archelos, Juan J; Suneetha, Lavanya M
Título:Comparative proteomics of the Mycobacterium leprae binding protein myelin P0: its implication in leprosy and other neurodegenerative diseases
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Fonte:s.l; s.n; 2004. 8 p. ilus, tab.
Resumo:Mycobacterium leprae, the causative agent of leprosy invades Schwann cells of the peripheral nerves leading to nerve damage and disfigurement, which is the hallmark of the disease. Wet experiments have shown that M. leprae binds to a major peripheral nerve protein, the myelin P zero (P0). This protein is specific to peripheral nerve and may be important in the initial step of M. leprae binding and invasion of Schwann cells which is the feature of leprosy. Though the receptors on Schawann cells, cytokines, chemokines and antibodies to M. leprae have been identified the molecular mechanism of nerve damage and neurodegeneration is not clearly defined. Recently pathogen and host protein/nucleotide sequence similarities (molecular mimicry) have been implicated in neurodegenerative diseases. The approach of the present study is to utilise bioinformatic tools to understand leprosy nerve damage by carrying out sequence and structural similarity searches of myelin P0 with leproma and other genomic database. Since myelin P0 is unique to peripheral nerve, its sequence and structural similarities in other neuropathogens have also been noted. Comparison of myelin P0 with the M. leprae proteins revealed two characterised proteins, Ferrodoxin NADP reductase and a conserved membrane protein, which showed similarity to the query sequence. Comparison with the entire genomic database (www.ncbi.nlm.nih.gov) by basic local alignment search tool for proteins (BLASTP) and fold classification of structure-structure alignment of proteins (FSSP) searches revealed that myelin P0 had sequence/structural similarities to the poliovirus receptor, coxsackie-adenovirus receptor, anthrax protective antigen, diphtheria toxin, herpes simplex virus, HIV gag-1 peptide, and gp120 among others. These proteins are known to be associated directly or indirectly with neruodegeneration. Sequence and structural similarities to the immunoglobin regions of myelin P0 could have implications in host-pathogen interactions, as it has homophilic adhesive properties. Although these observed similarities are not highly significant in their percentage identity, they could be functionally important in molecular mimicry, receptor binding and cell signaling events involved in neurodegeneration. (AU).
Descritores:Sequência de Aminoácidos
Proteínas de Bactérias/GE/ME
Biologia Computacional
Hanseníase/*ME/MI
Proteínas de Membrana/*
Modelos Moleculares
Mimetismo Molecular
Dados de Sequência Molecular
Mycobacterium leprae/*GE/ME
Proteína P0 da Mielina/CH/*GE/ME
Doenças Neurodegenerativas/*ME
Ligação Proteica
Conformação Proteica
Proteômica/*
Receptores Virais/CH/ME
Limites:HUMANO
Localização:BR191.1; 09195/S


  2 / 5 HANSEN  
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Id:16217
Autor:Rambukkana, Anura
Título:Molecular basis for the peripheral nerve predilection of mycobacterium leprae
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Fonte:s.l; s.n; 2001. 7 p. ilus.
Descritores:ANTIGENOS DE BACTÉRIAS
PAREDE CELULAR
GLICOLIPIDIOS
LAMININA
HANSENIASE
HANSENIASE
GLICOPROTEINAS DE MEMBRANAS
MODELOS BIOLOGICOS
MYCOBACTERIUM LEPRAE
NERVOS PERIFÉRICOS
LIGAÇAO PROTÉICA
CÉLULAS DE SCHWANN
TROPISMO
Localização:BR191.1; 08702/s


  3 / 5 HANSEN  
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Id:15776
Autor:Aleman, M; Barrera, S. de la; Fink, S; Finiasz, M; Arinna, M. H; Pizzariello, G; Sasiain, M. del C
Título:Interleukin-12 amplifies the M. leprae hsp65-cytotoxic responses in the presence of tumor necrosis factor-alpha and interferon-gamma generating CD56+ effector cells: interleukin-4 downregulates this effect
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Fonte:s.l; s.n; 2000. 9 p. tab, graf.
Descritores:HANSENIASE
MYCOBACTERIUM LEPRAE
ANTIGENOS CD56
CHAPERONINAS
CITOTOXICIDADE IMUNOLOGICA
SINERGISMO DE DROGAS
SOROS IMUNES
INTERFERON TIPO II
INTERLEUCINA-10
INTERLEUCINA-12
INTERLEUCINA-12
INTERLEUCINA-12
INTERLEUCINA-4
INTERFASE
LEUCOCITOS MONONUCLEARES
LEUCOCITOS MONONUCLEARES
TRANSFORMAÇAO LINFOCITICA
COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE
LIGAÇAO PROTÉICA
LINFOCITOS T CITOTOXICOS
LINFOCITOS T CITOTOXICOS
FATOR DE NECROSE DE TUMOR
FATOR DE NECROSE DE TUMOR
FATOR DE NECROSE DE TUMOR
Localização:BR191.1; 07463/s


  4 / 5 HANSEN  
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Id:13842
Autor:Hussain, R; Menz, B; Dockrell, H. M; Chiang, T. J
Título:Recognition of Mycobacterium leprae recombinant 18000 MW epitopes by IgG subclasses in leprosy
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Fonte:s.l; s.n; 1995. 8 p. tab, graf.
Descritores:HANSENIASE
HANSENIASE LEPROMATOSA
HANSENIASE TUBERCULOIDE
MYCOBACTERIUM LEPRAE
ANTICORPOS ANTIBACTÉRIAS
ESPECIFICIDADE DE ANTICORPOS
REAÇOES ANTIGENO-ANTICORPO
ELISA
MAPEAMENTO DE EPITOPOS
EPITOPOS
SWITCHING DE IMUNOGLOBULINA
PESO MOLECULAR
PEPTIDIOS
LIGAÇAO PROTÉICA
PROTEINAS RECOMBINANTES
Localização:BR191.1; 06825/s


  5 / 5 HANSEN  
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Id:13636
Autor:Byrd, Sally; Gelber, Robert; Bermudez, Luiz E
Título:Roles of soluble fibronectin and B1 integrin receptors in the binding of Mycobacterium leprae to nasal epithelial cells
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Fonte:s.l; s.n; 1993. 6 p. tab.
Descritores:HANSENIASE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
SEQUENCIA DE AMINOACIDOS
PROTEINAS DE BACTÉRIAS
LINHAGEM CELULAR
EPITÉLIO
FIBRONECTINAS
INTEGRINAS
LIGANTES
MACROFAGOS
SEPTO NASAL
SEPTO NASAL
OLIGOPEPTIDIOS
ENSAIO RADIOLIGANTE
LIGAÇAO PROTÉICA
SOLUBILIDADE
Localização:BR191.1; 06552/s



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